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Document 1062
DOCN M9651062
TI Risk of hepatitis C seroconversion after occupational exposures in
health care workers. Italian Study Group on Occupational Risk of HIV and
Other Bloodborne Infections.
DT 9505
AU Puro V; Petrosillo N; Ippolito G; Centro di Riferimento AIDS, L.
Spallanzani Hospital, Rome, Italy.
SO Am J Infect Control. 1995 Oct;23(5):273-7. Unique Identifier : AIDSLINE
MED/96126293
AB BACKGROUND: To determine the incidence of hepatitis C virus (HCV)
seroconversion, health care workers reporting an occupational exposure
with blood or other risk-prone body materials from a patient known to be
seropositive for HCV antibody were enrolled. METHODS: HCV seroconversion
within 6 months of a reported exposure was assessed by second-generation
enzyme immunoassay and immunoblot assay. RESULTS: From January 1992
through December 1993, 331 (51%) hollow-bore needlesticks, 105 (16.5%)
suture needle or sharp object injuries, 85 (13%) mucous membrane
contaminations, and 125 (19.5%) skin contaminations were reported. Four
HCV seroconversions were observed after hollow-bore needlesticks (1.2%;
95% CI 0.3% to 3.0%); no seroconversions occurred after other routes of
exposure. Blood-filled needlesticks and source patient coinfection with
HIV appeared to be associated with a higher risk of seroconversion.
CONCLUSIONS: The risk of HCV seroconversion after occupational exposure
appears to be low but is not negligible. Aggressive implementation of
universal precautions is important for preventing risk-prone exposure,
but safer devices are also needed.
DE Adolescence Adult Aged Blood-Borne Pathogens *Disease Transmission,
Patient-to-Professional/STATISTICS & NUMER DATA Female Hepatitis
C/EPIDEMIOLOGY/IMMUNOLOGY/*TRANSMISSION Hepatitis C
Antibodies/BIOSYNTHESIS/*BLOOD Human Immunoblotting Immunoenzyme
Techniques Incidence Italy/EPIDEMIOLOGY Male Middle Age
Occupational Exposure/*STATISTICS & NUMER DATA *Personnel, Hospital
Risk Factors Support, Non-U.S. Gov't JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).